BIOMARKERS
With the emergence of personalized medicine and the ability to predict medical diagnosis/prognosis based on a patient’s genetic makeup, more and more researchers have begun to incorporate biomarker analysis into their research.
Genomics in Biomarkers
Basic scientists identify and analyze molecular biomarkers in their pathways of interest to get a clearer understanding of these pathways and the resulting physiology or pathology.
Drug developers incorporate biomarker discovery into their R&D, pre-clinical, and clinical workflows to develop targeted therapies which will result in better efficacy. Some biomarkers that have resulted in effective targeted drugs include BRAF, HER2, EGFR, and KRAS to name a few. Biomarkers have recently taken on added significance in cancer diagnosis and treatment but also play an important role in various other therapeutic areas.
In medicine, healthcare practitioners rely on pharmacogenomics testing to analyze a patient’s genomic profile in order to accurately prescribe the most effective medications with as few side-effects as possible.
Applications
GENEWIZ offers a number of genomics solutions to assist in biomarker research and discovery.
-
RNA-Seq
The throughput of RNA-Seq allows researchers to analyze the entire transcriptome of an organism and thereby discover molecular biomarkers related to gene expression, alternative transcripts or splicing events.
-
Whole Genome Sequencing
Full-service whole genome sequencing allows the comprehensive analysis of entire genomes to reveal implicated genotypes or discover previously unknown SNPs, genes, or other biomarkers.
-
Gene Synthesis
Advance your proteomic biomarker studies by using our gene synthesis services to quickly obtain your gene of interest.
-
Bioinformatics Solutions
Advanced bioinformatics solutions are available to help analyze complex data sets to identify potential biomarkers quickly and efficiently.
RNA-Seq
The throughput of RNA-Seq allows researchers to analyze the entire transcriptome of an organism and thereby discover molecular biomarkers related to gene expression, alternative transcripts or splicing events.
Cancer Panels
We offer commercially available hotspot cancer panels that target well-characterized cancer biomarkers, as well our proprietary OncoGxOne™ Discovery cancer panels for biomarker discovery and research.
Whole Genome Sequencing
Our full-service whole genome sequencing solutions allow the comprehensive analysis of entire genomes to reveal implicated biomarkers or discover previously unknown biomarkers.